Genelex has submitted multiple claims with several carriers, almost all of which were paid at an acceptable rate. However sometimes we do have to supply more information.

If this is the case, please download the following packet that Genelex has used in the past to help insurance companies understand the importance of Tamoxitest. We have been able to successfully help our clients obtain reimbursement.

• Insurance Appeal letter: Download a template to submit your letter to appeal for insurance coverage.
  
  
• Research publications: This packet contains a list of research documents that will help you and your insurance company understand the medical importance of Tamoxifen Resistance DNA testing.
  
  
  1. Association Between CYP2D6 Polymorphisms and Outcomes Among Women with Early stage Breast Cancer Treated With Tamoxifen
     
     
  2. Mayo Research: Endoxifen, But Not 4-hydroxytamoxifen, Degrades The Estrogen Receptor In Breast Cancer Cells: A Differential Mechanism Of Action Potentially Explaining CYP2D6 Effect
     
     
  3. Polymorphism in the CYP2D6 Tamoxifen-Metabolizing Gene Influences Clinical Effect but Not Hot Flashes: Data From the Italian Tamoxifen Trial.
     
     
  4. Pharmacogenetics of Tamoxifen Biotransformation Is Associated With Clinical Outcomes of Efficacy and Hot Flashes.
     
     
  5. Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients.
     
     
  6. Pharmacogenetics and Pharmacogenomics of Anticancer Agents.
     
     
  7. Breast Cancer Treatment Outcome With Adjuvant Tamoxifen Relative to Patient CYP2D6 and CYP2C19 Genotypes.
     
     
  8. Mechanisms of endocrine resistance and novel therapeutic strategies in breast cancer.
     
     
  9. Pharmacokinetics of Tamoxifen.
     
     
  10. Cancer treatment and pharmacogenetics of cytochrome P450 enzymes.

Please contact Kristine Ashcraft at kashcraft@genelex.com or (206)-826-1957 to discuss insurance questions.

3000 First Ave., Suite One, Seattle, WA 98121

800 523-3080